Mechanism of action Vitamin B1 - Thiamine
VITAMIN B1 ® is a thiamine-based drug, a key vitamin in balancing the energy and biosynthetic state of the human body. Concentrated in tissues such as the heart and the nervous system, mainly in the form of thiamine pyrophosphate, it acts as a cofactor of decarboxylase and transketolase, involved respectively in the generation of energy from various macromolecules and in the synthesis of nucleic acids. The deficiency of this vitamin, fortunately rare and present especially in some risk categories such as alcoholics, manifests itself with an intense neuropathy characterized by intense pain in the extremities, seizures and in the most severe cases with encephalopathy. Under these conditions, the intake of parenteral thiamine can cause a rapid regression of symptoms, significantly improving the patient's health conditions. Studies performed and clinical efficacy 2. EARLY VITAMIN B1 DEFICIENCY IN DEVELOPING COUNTRIES Ann Trop Paediatr. 2004 December; 24 (4): 357-60. Thiamine deficiency - a cause of infantile ataxia that should not be ignored. Ogunlesi TA. Important study aimed at educating physicians operating in developing countries about the presence of thiamine deficiency, also responsible for ataxia in pediatric patients. 2. EATING HABITS AND VITAMIA B6 DEFICIENCIES Brain Dev. 2010 Aug;32(7):556-63. Epub 2009 Sep 26. Thiamine deficiency encephalopathy due to excessive intake of isotonic drink or too strict dietary therapy in Japanese children. Saeki K, Saito Y, Komaki H, Sakakibra T, Nakagawa E, Sugai K, Sakuma H, Sasaki M, Honda T, Hayashi H, Katori N, Miyahara Y. Very interesting study that investigates the possible effects of some unhealthy eating habits, such as excessive consumption of isotonic drinks, capable of reducing blood concentrations of thiamine, thus facilitating the appearance of serious side effects. 3. LACTIC ACIDOSIS AND VITAMIN B1 DEFICIENCY Clin Nutr. April 1993; 12 (2): 108-11. Lactic acidosis in thiamine deficiency. Madl C, Kranz A, Liebisch B, Traindl O, Lenz K, Druml W. Study that associates lactic acidosis found in severely malnourished patients with a marked deficiency of thiamine pyrophosphate, therefore, with the inability to effectively use the common aerobic glycolytic pathways. Method of use and dosage. VITAMIN B2 ® Injectable solution for intramuscular use of 2 mg of thiamine hydrochloride per ml of solution: the treatment of thiamine deficiency syndromes, so severe that they cause neuropathy, involves the intramuscular administration of 1 mg of thiamine per day or every other day, according to therapeutic needs. In either case, medical supervision is required. Warnings Vitamin B2 Angelini Urto ® - Thiamine Before injecting the medicine it would be advisable to check the physical-chemical characteristics of the product, avoiding its intake in the presence of insoluble residues or noticeable opalescence. Alcohol abuse is often associated with thiamine deficiency states sustained by both reduced dietary intake and impaired intestinal absorbency. PREGNANCY AND LACTATION Given the absence of clinical trials and given the intended pharmaceutical form of this medicine, it is not recommended to use VITAMIN B1 ® during pregnancy and possibly also in the period after lactation. Interactions The pharmacokinetic characteristics and the half-life of thiamine could undergo significant variations after concomitant ingestion of furosemide and anticonvulsants. In addition, the intake of 2 florouracil, which prevents the synthesis of thiamine pyrophosphate, could reduce the biological activity of this vitamin. Contraindications Vitamin B2 Angelini Urto ® - Thiamine The intake of VITAMIN B5 ® is contraindicated in case of hypersensitivity to the active principle or to any of its excipients. Undesirable effects: side effects The ingestion of intramuscular thiamine has been associated on rare occasions with the appearance of allergic reactions characterized by intense itching especially at the injection site, angioedema, urticaria, tachycardia, shortness of breath and in the most severe cases shock. anaphylactic. Note VITAMIN B2 ® can only be sold with a prescription.