VITAMIN K SALF ® is a Vitamin K-based drug
THERAPEUTIC GROUP: Vitamin K and other antihemorrhagics
Indications VITAMIN K SALF ® - Vitamin K (menadiol)
VITAMIN K SALF ® is indicated in the prevention and treatment of neonatal haemorrhagic diseases or associated with vitamin K deficiency.
Mechanism of action VITAMIN K SALF ® - Vitamin K (menadiol)
VITAMIN K SALF ® supplies vitamin K, in the form of a water-soluble compound known as menadiol sodium diphosphate, whose pharmacodynamic characteristics are however totally superimposable to those of the more common phytomenadione.
In fact, menadiol is able to assist the activity of a specific carboxylase, involved in gamma carboxylation, therefore in the activation of some protein factors actively involved in the coagulation process.
However, recent studies have shown how this vitamin can, among other things:
- Promote regular growth;
- Prevent blood dripping associated with chronic diseases especially affecting the gastro-enteric and genito-urinary system;
- Support the anti-haemorrhagic activity, compromised during prolonged antibiotic therapy.
Consequently, a vitamin K deficiency could also seriously affect the patient's state of health, especially if they are young, as occurs in children suffering from haemorrhagic disease of the newborn.
Studies carried out and clinical efficacy
1.VITAMIN KE BONE HEALTH
PM R. 2011 Jun;3(6 Suppl 1):S82-7.
Vitamin K: fracture prevention and beyond.
Falcone TD, Kim SS, Cortazzo MH.
Interesting study, which proposes a re-evaluation of the works in the literature concerning the effects of vitamin K on bone health. The data shows how diets rich in this vitamin can prevent fractures and bone pathologies.
2. THE ROLE OF VITAMIN K IN CYSTIC FIBROSIS
Cochrane Database Syst Rev. 2011 Jan 19;(1):CD008482.
Vitamin K supplementation for cystic fibrosis.
Jagannath VA, Fedorowicz Z, Thaker V, Chang AB.
Cystic fibrosis is a multi-organ disease often associated with lipid malabsorption syndromes, which inevitably affect the blood concentrations of fat-soluble vitamins.
For this reason, supplementation with vitamin K could be useful in preserving the correct coagulation process, reducing the risk of bleeding and associated complications.
3. THE DEFICITY OF VITAMIN K IN CHOLESTASIS
J Pediatr Gastroenterol Nutr. 2009 Jul;49(1):78-84.
Prevalence of subclinical vitamin K deficiency in cholestatic liver disease.
Strople J, Lovell G, Heubi J.
Study that demonstrates how cholestatic liver disease can affect, albeit in a subclinical form, the blood concentrations of vitamin K. This evidence underlines the importance of resorting to supplementation with this vitamin in such circumstances, in order to avoid the appearance of haemorrhagic reactions .
Method of use and dosage
VITAMINA K SALF ®
Solution for injections of 10 - 50 mg of vitamin K per 2 ml of solution.
The definition of the dosage should be defined by the specialist doctor, based on the clinical characteristics of the patient, the coagulation picture, the age and the possible presence of contextual pathologies.
All treatment should be supervised by your doctor in order to avoid the appearance of side effects.
Intake of VITAMIN K SALF ® intravenously should preferably take place in a hospital setting.
Warnings VITAMIN K SALF ® - Vitamin K (menadiol)
Before administering vitamin K, the doctor should carefully evaluate the patient's health conditions, evaluating the possible presence of pathological conditions, such as liver disease and thrombotic or atherosclerotic pathologies, incompatible with the intake of VITAMIN K SALF ®.
In patients suffering from liver disease of any degree, the observed result in terms of bleeding control could significantly differ from that expected, therefore requiring a possible adjustment of the dosage used and also taking into account the increased risk of developing allergic reactions.
Before taking VITAMIN K SALF ® it is necessary to check the clarity of the solution and the absence of visible precipitates.
PREGNANCY AND BREASTFEEDING
The intake of VITAMIN K SALF ® during pregnancy and in the subsequent period of breastfeeding, should be carried out only in case of real need and under strict medical supervision.
The concomitant intake of antibiotics or salicylates could lead to an increase in the need for vitamin K, therefore requiring an adjustment of the pharmacological dosage used.
It is useful to remember, in the light of its biological role, how vitamin K could antagonize the anticoagulant effects of dicumarins.
Contraindications VITAMIN K SALF ® - Vitamin K (menadiol)
VITAMIN K SALF ® is contraindicated in case of hypersensitivity to the active ingredients or related excipients.
Undesirable Effects - Side Effects
Bronchospasm, cyanosis, injection site pain, pruritus, tachycardia were some of the most frequently observed adverse reactions in adults following intake of VITAMIN K SALF ®.
In children, on the other hand, jaundice, constipation, abdominal pain, skin rashes, and general malaise were observed.
Fortunately, in all cases, the symptoms returned with the simple suspension of medical therapy.
VITAMIN K SALF ® is a drug that can only be sold with a prescription.
The information on VITAMIN K SALF ® - Vitamin K (menadiol) published on this page may be out of date or incomplete. For a correct use of this information, see the Disclaimer and useful information page.